小分子交联剂蛋白-蛋白以及蛋白-核酸大分子复合体材料-UDP糖丨MOF丨金属有机框架丨聚集诱导发光丨荧光标记推荐西安齐岳生物

带有光保护的醌甲基化物（QM）小分子化学交联剂。使用这些交联剂，可以通过远紫外光（365 nm）诱导从而特异性的释放活化的醌甲基化物进行蛋白质-蛋白质以及蛋白质-核酸之间的交联。仅能够使得蛋白交联获得时间分辨率，引入的强活性的醌甲基化物可与许多邻近的亲核性的残基，如 His、Lys、Tyr 等侧链反应而产生蛋白交联。并且这些交联剂不仅使适用单个蛋白的交联，也可以在细胞裂解液以及在活体细胞中诱导蛋白-蛋白发生化学交联。

合成一端带有醌甲基化物前体，另一端带有NHS酯基的小分子化学交联剂（NHQM）。通过对14-3-3 目标蛋白紫外光照射与否以及加不加NHQM交联剂处理，发现只有在加入NHQM交联剂并且紫外光照射下才会诱导产生14-3-3二聚体。并且这种二聚体的产生可以很好的通过光控实时的产生。进一步证明了NHQM交联剂的其中一个实用性-可以快速鉴别蛋白聚合情况，并且利用化学交联质在14-3-3蛋白上与醌甲基化物反应的亲和性残基。

接着，测试了NHQM在细胞内的交联情况，发现细胞体内交联效率较弱，这可能与短时间内NHQM穿膜性和溶解性差有关，而增长穿膜时间NHS会快速水解从而使交联失效

齐岳供应产品：

产品列表：

DHB

2,5-dihydroxybenzoic acid

CAS Number: 490-79-9

CHCA

α-Cyano-4-hydroxycinnamic acid

CAS Number: 28166-41-8

HABA

2-(4'-Hydroxybenzeneazo)benzoic acid

CAS Number: 1634-82-8

Sinapinic Acid

CAS Number: 530-59-6

THAP

2',4',6'-Trihydroxyacetophenone monohydrate

CAS Number: 480-66-0

DHAP

2',4',-Dihydroxyacetophenone

CAS Number: 89-84-9

MBT

MBT MALDI matrix, 2-Mercaptobenzothiazole

CAS Number: 149-30-4

色谱相关试剂

产品列表：

LCMS Grade Solvents：

LCMS Acetonitrile CAS Number: 75-05-8

LCMS Acetonitrile with 0.1% Acetic Acid

LCMS Acetonitrile with 0.1% Formic Acid

LCMS Acetonitrile with 0.1% TFA

LCMS Acetonitrile with 0.1% Formic Acid and 0.01% TFA

LCMS Water with 0.1% Acetic Acid

LCMS Water with 0.1% Formic Acid

LCMS Methanol CAS Number: 67-56-1

LCMS Water CAS Number: 7732-18-5

HPLC Grade Solvents：

HPLC Acetone CAS Number: 67-64-1

HPLC Acetonitrile CAS Number: 75-05-8

HPLC Acetonitrile with 0.1% TFA

HPLC Cyclohexane CAS Number: 110-82-7

HPLC Dimethyl sulfoxide CAS Number: 67-68-5

HPLC Methanol CAS Number: 67-56-1

HPLC Water CAS Number: 7732-18-5

Acetic Acid Ampules (Proteomics Grade) CAS Number: 64-19-7

Formic Acid Ampules (Proteomics Grade) CAS Number: 64-18-6

TFA Ampules (Proteomics Grade) CAS Number: 76-05-1

HFBA Ampules (Proteomics Grade) CAS Number: 375-22-4

Formic Acid + TFA Ampules (Proteomics Grade)

LCMS Mobile Phases Sampler Pack

Additives & Ion Pairing：

Proteochem蛋白交联试剂，进口蛋白交联试剂

Protein crosslinkers （蛋白交联相关试剂）：

Heterobifunctional Crosslinkers异型双功能交联剂：

SMCC Crosslinker

Succinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate

CAS Number: 64987-85-5

Sulfo-SMCC Crosslinker

Sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate

CAS Number: 92921-24-9

Sulfo-SANPAH Crosslinker

N-Sulfosuccinimidyl-6-[4'-azido-2'-nitrophenylamino] hexanoate

CAS Number: 102568-43-4

SMPH Crosslinker

Succinimidyl-6-[ß-maleimidopropionamido]hexanoate

PDPH Crosslinker

3-[2-Pyridyldithio]propionyl hydrazide) is a cleavable, carbohydrate reactive

MBS Crosslinker

m-Maleimidobenzoyl-N-hydroxysuccinimide ester

CAS Number: 58626-38-3

Sulfo-MBS Crosslinker

m-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester

SPDP Crosslinker

N-Succinimidyl 3-[2-pyridyldithio]-propionate

CAS Number: 68181-17-9

LC-SPDP Crosslinker

Succinimidyl 6-(3-[2-pyridyldithio]-propionamido)hexanoate

Sulfo-LC-SPDP Crosslinker

Sulfosuccinimidyl 6-(3'-[2-pyridyldithio]-propionamido)hexanoate

SIA Crosslinker

N-Succinimidyl iodoacetate

CAS Number: 39028-27-8

SBA Crosslinker

N-Succinimidyl bromoacetate; SIB crosslinker

CAS Number: 42014-51-7

SMPB Crosslinker

N-Succinimidyl 4-[4-maleimidophenyl]butyrate

CAS Number: 79886-55-8

BMPS Crosslinker

N-(ß-Maleimidopropyloxy)succinimide ester

CAS Number: 55750-62-4

EMCS Crosslinker

N-[e-Maleimidocaproyloxy]succinimide ester

CAS Number: 55750-63-5

GMBS Crosslinker

N-[Gamma-Maleimidobutyryloxy] Succinimide

CAS Number: 80307-12-6

ANB-NOS Crosslinker

N-5-Azido-2-nitrobenzoyloxysuccinimide

CAS Number: 60117-35-3

Homobifunctional Crosslinkers同型双功能交联剂：

BS3 Crosslinker

Bis[sulfosuccinimidyl] suberate

CAS Number: 82436-77-9

DSS Crosslinker

Disuccinimidyl suberate N-hydroxysuccinimide ester

CAS Number: 68528-80-3

BS2G Crosslinker

BS2G; Bis[Sulfosuccinimidyl] glutarate

DSG Crosslinker

Disuccinimidyl glutarate; Di(N-succinimidyl

CAS Number: 79642-50-5

DSP Crosslinker

3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester)

CAS Number: 57757-57-0

DTSSP Crosslinker

3,3´-Dithiobis[sulfosuccinimidylpropionate

CAS Number: 81069-02-5

Sulfo-EGS Crosslinker

glycolbis(sulfosuccinimidylsuccinate)

CAS Number: 167410-92-6

EGS Crosslinker

Ethylene glycolbis(succinimidylsuccinate)

CAS Number: 70539-42-3

DST Crosslinker

CAS Number: 62069-75-4

Zero-Length Crosslinkers - EDC-HCl, Sulfo-NHS & NHS：

EDC-HCl

1- Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride

CAS Number: 25952-53-8

Sulfo-NHS

N-hydroxysulfosuccinimide Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid

CAS Number: 106627-54-7

进口蛋白质交联试剂列表，Sulfo-LC-SPDP

Protein crosslinkers （蛋白交联相关试剂）：

Heterobifunctional Crosslinkers异型双功能交联剂：

SMCC Crosslinker CAS Number: 64987-85-5

Sulfo-SMCC Crosslinker CAS Number: 92921-24-9

Sulfo-SANPAH Crosslinker CAS Number: 102568-43-4

SMPH Crosslinker

PDPH Crosslinker

MBS Crosslinker CAS Number: 58626-38-3

Sulfo-MBS Crosslinker

SPDP Crosslinker CAS Number: 68181-17-9

LC-SPDP Crosslinker

Sulfo-LC-SPDP Crosslinker

SIA Crosslinker CAS Number: 39028-27-8

SBA Crosslinker CAS Number: 42014-51-7

SMPB Crosslinker CAS Number: 79886-55-8

BMPS Crosslinker CAS Number: 55750-62-4

EMCS Crosslinker CAS Number: 55750-63-5

GMBS Crosslinker CAS Number: 80307-12-6

ANB-NOS Crosslinker CAS Number: 60117-35-3

Homobifunctional Crosslinkers同型双功能交联剂：

BS3 Crosslinker CAS Number: 82436-77-9

DSS Crosslinker CAS Number: 68528-80-3

BS2G Crosslinker

DSG Crosslinker CAS Number: 79642-50-5

DSP Crosslinker CAS Number: 57757-57-0

DTSSP Crosslinker CAS Number: 81069-02-5

Sulfo-EGS Crosslinker CAS Number: 167410-92-6

EGS Crosslinker CAS Number: 70539-42-3

DST Crosslinker CAS Number: 62069-75-4

Zero-Length Crosslinkers - EDC-HCl, Sulfo-NHS & NHS：

EDC-HCl CAS Number: 25952-53-8

Sulfo-NHS CAS Number: 106627-54-7

Deuterated Crosslinker BS3-d4

Deuterated Crosslinker BS2G-d4

Deuterated Crosslinker DSS-d4

上述产品齐岳生物均可供应，仅用于科研！

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