标题：Abstract 238: Sub-Endothelial Matrix Targeted Liposomal Nanoparticles For Vascular Therapeutics（用于血管*的亚内皮基质靶向脂质体纳米粒子）

链接：https://xueshu.baidu.com/usercenter/paper/show?paperid=a250e60fa47edb2778626375e13802e8&site=xueshu_se

作者：JS Cudnik，PC West，RK Fisher，Sam Mattern-Schain，M Best，SS Kirkpatrick，MB Freeman，OH Grandas，DJ Mountain

摘要：

Objectives: Vascular intervention results in intimal denudation, exposure of the sub-endothelial matrix, and subsequent intimal hyperplasia (IH), under the control of numerous remodeling mechanisms. Reduction of IH-induced restenosis may be achieved by manipulation of these remodeling pathways through targeted molecular inhibition. Spatially-controlled nanoparticles designed to co-localize to exposed sub-endothelial matrices could provide an optimal delivery system for targeted vascular therapeutics. To his end, we aimed to develop the framework for a surface-modified liposomal drug delivery platform designed to preferentially bind collagen type IV. Methods: Non-targeted control liposomes (NTL) were formed with bulk DOPC-PEG, 30% cholesterol, and 0.1 mol% Rhodamine-DOPE. DSPE-PEG-DBCO lipids were conjugated to peptides previously shown to bind collagen IV via copper-free click chemistry and inserted at 5 mol% to form collagen-targeting liposomes (CTL), either at hydration (PreCTL) or by post-insertion via micellar transfer (PostCTL).

译文：

目的：在多种重塑机制的控制下，血管介入导致内膜剥脱、亚内皮基质暴露和随后的内膜增生（IH）。通过靶向分子抑制操纵这些重塑途径，可以减少IH诱导的再狭窄。设计用于共定位暴露的亚内皮基质的空间控制纳米粒子可以为靶向血管*提供*佳的递送系统。为此，我们的目标是开发一种表面修饰的脂质体药物递送平台的框架，该平台旨在优先结合IV型胶原蛋白。

方法：非靶向对照脂质体（NTL）由散装DOPC-PEG、30%胆固醇和0.1 mol%罗丹明DOPE形成。将DSPE-PEG-DBCO脂质与之前显示的通过无铜点击化学结合IV型胶原的肽偶联，并在水合（PreCTL）或通过胶束转移（PostCTL）插入后以5mol%插入形成胶原靶向脂质体（CTL）。

DOI：10.3969/j.issn.1008-987x.2021.03.09

西安齐岳生物提供相关产品：

DSPE-PEG-acid

DSPE-PEG4-acid

DSPE-PEG-Ald

DSPE-PEG-Amine，1069-79-0

DSPE-PEG-azide

DSPE-PEG5-azide

DSPE-PEG-Biotin

DSPE-PEG-Boronate

DSPE-PEG-CH2COOH

DSPE-PEG-COOH

DSPE-PEG-Cy3

DSPE-PEG-Cy5

DSPE-PEG-DBCO

DSPE-PEG-FITC

DSPE-PEG-Folate

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