文献：(177)Lu-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics

文献链接：https://xueshu.baidu.com/usercenter/paper/show?paperid=c78a5baea5c0fadb51c1d4fff76ee436&site=xueshu_se

作者：L Jing，J Shi，D Fan，Y Li，R Liu，Z Dai，F Wang，J Tian

摘要：This Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG2000-DOTA), followed by chelating radioisotope of 177Lu. Its applications in optical and nuclear imaging of tumor uptake and biodistribution, as well as photothermal killing of cancer cells, were investigated. It was found that the obtained cerasome could act efficiently as fluorescence contrast agent as well as nuclear imaging tracer. Encapsulating ICG into cerasome could protect ICG from degradation, aggregation, and fast elimination from body, resulting in remarkable improvement in near-infrared fluorescence imaging, photothermal stability, and in vivo pharmacokinetic profile.

本文报道了通过掺入1,2-二硬脂酰基-sn-甘油-3-磷乙醇胺-N-[羧基（聚乙二醇）2000]-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸单酰胺（DSPE-PEG2000-DOTA），然后加入177Lu的螯合放射性同位素，制备了一种包封吲哚菁绿（ICG）的坚固的治疗性陶瓷体。

研究了其在肿瘤摄取和生物分布的光学和核成像以及细胞的光热杀伤中的应用。研究发现，所获得的陶瓷体可以作为荧光造影剂和核成像示踪剂。

将ICG封装在陶瓷体内可以保护ICG免受降解、聚集和快速从体内消除，从而显著改善近红外荧光成像、光热稳定性和体内药代动力学特性。

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DSPE-PEG-AC

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DSPE-PEG-CHEMS

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