文献：Research on paclitaxel microemulsion

文献链接：https://xueshu.baidu.com/usercenter/paper/show?paperid=711ecf9ab37cd13cc80ce6b099adfed6&site=xueshu_se

作者：阎家麒，王惠杰，童岩，臧莹安，王九一

摘要：

OBJECTIVE:To study the preparation of microemulsion containing paclitaxel for both intravenous and oral administration,its stability and bioavailability. METHODS:Corn oil was hydrated and sonicated.EPC,paclitaxel and PEG-DSPE were combined in CHCl-3.A thick lipid film was obtained after drying under a stream of N-2 and vacuum evacuation.The hydrated oil was added directly to the thin phospholipid film,vortexed and then sonicated.The mixture was passed through the Microfluidizer for microemulsified. RESULTS:The particle size was 50～100 nm,the encapsulation efficiency was ≥99.2% and the absolute bioavailability of intravenous and oral adminstration was 107.7% and 22.4%,respectively. CONCLUSION:This study developed a new formulation for paclitaxel.

目的：研究紫杉醇静脉和口服微乳的制备、稳定性和生物利用度。

方法：将玉米油水合并超声处理。EPC、紫杉醇和PEG-DSPE在CHCl-3中混合。在N-2流和真空抽空下干燥后获得厚脂质膜。将水合油直接加入薄磷脂膜中，涡旋，然后超声处理。将混合物通过微流化器进行微乳化。

结果：粒径为50～100nm，包封率≥99.2%，静脉和口服给药的绝对生物利用度分别为107.7%和22.4%。

结论：本研究开发了一种新的紫杉醇制剂。

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