DSPE-PEG-FA修饰纳米颗粒用于增强*细胞摄取与核定位释放

链接：https://pubs.acs.org/doi/abs/10.1021/acsami.5b05038

作者：杨丽，林金艳，杨祥瑞，李彦修，吴世超，玉皇，叶社芳，谢丽娅，戴理宗，侯真庆

摘要：

结合丝裂霉素C (MMC)–磷脂复合物可提高药物包封率并减少药物过早释放以及DSPE-PEG-叶酸 (DSPE-PEG-FA) 可用于特异性靶向*的优势，我们报道了一种简单的一锅自组装路线来制备载有MMC–磷脂复合物的DSPE-PEG基纳米颗粒 (MP-PEG-FA NPs)。共聚焦成像和流式细胞术均表明，在细胞摄取和细胞内药物递送后，MMC分布到细胞核中。更重要的是，全身给药的MP-PEG-FA NPs可增加HeLa*裸鼠的血液持久性和增强的*蓄积。本研究介绍了一种简单有效的策略来设计基于*癌药物–磷脂复合物的靶向药物递送系统，以实现持续/控制的药物释放。

译文：

Integrating advantages of mitomycin C (MMC)–phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC–phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug–phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.

西安齐岳生物提供相关产品：

DSPE-PEG-Boronate

DSPE-PEG-CH2COOH

DSPE-PEG-COOH

DSPE-PEG-Cy3

DSPE-PEG-Cy5

DSPE-PEG-DBCO

DSPE-PEG-FITC

DSPE-PEG-Folate

DSPE-PEG-IA

DSPE-PEG-Mal

DSPE-PEG-NH2

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