DSPE-PEG-MTX修饰纳米胶束在头颈部鳞状细胞癌中的靶向应用研究

链接：https://www.tandfonline.com/doi/abs/10.2217/nnm-2016-0382

作者：朱敏慧，陈世才，华立波，张彩云，陈梦洁，陈东辉，董银梅，张莹莹，李萌，宋宪民，陈怀文  ，郑洪亮

摘要：

目的：利用载盐霉素的DSPE-PEG-MTX（由DSPE-PEG2000-NH2和甲氨蝶呤合成）纳米胶束（M-SAL-MTX）同时靶向作用于头颈部鳞状细胞癌（HNSCC）细胞和*干细胞（CSC）。

材料与方法：评估M-SAL-MTX的表征、**活性和作用机制。

结果与结论：与单一甲氨蝶呤和盐霉素*相比，M-SAL-MTX对HNSCC CSC和非CSC均显示出增强的抑制作用。在携带HNSCC异种移植瘤的裸鼠中，M-SAL-MTX抑制*生长的效果优于其他对照组（包括甲氨蝶呤和盐霉素联合用药）。因此，M-SAL-MTX可能提供一种同时靶向HNSCC CSC和HNSCC细胞的*HNSCC的策略。

Abstract

Aim: To target both head and neck squamous cell carcinoma (HNSCC) cells and cancer stem cells (CSCs) by salinomycin-loaded DSPE-PEG-MTX (synthesized using DSPE-PEG2000-NH2 and methotrexate) nanomicelles (M-SAL-MTX). Materials & methods: The characterization, antitumor activity and mechanism of M-SAL-MTX were evaluated. Results & conclusion: M-SAL-MTX showed enhanced inhibitory effect toward both HNSCC CSCs and non-CSCs compared with a single treatment of methotrexate and salinomycin. In nude mice-bearing HNSCC xenografts, M-SAL-MTX suppressed tumor growth more effectively than other controls including combination of methotrexate and salinomycin. Therefore, M-SAL-MTX may provide a strategy for treating HNSCC by targeting both HNSCC CSCs and HNSCC cells.

西安齐岳生物提供相关产品：

DSPE-PEG-NB

DSPE-PEG-NBD

DSPE-PEG-NPC

DSPE-PEG-NTA-NI

DSPE-PEG-PCL

DSPE-PEG-PDP

DSPE-PEG-PEI

DSPE-PEG-PLA

DSPE-PEG-PLGA

DSPE-PEG-Progestrone

DSPE-PEG-RGD

DSPE-PEG-SC

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