将DSPE-PEG-DOX整合入脂质功能化金纳米棒实现线粒体靶向协同治疗-UDP糖丨MOF丨金属有机框架丨聚集诱导发光丨荧光标记推荐西安齐岳生物

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将DSPE-PEG-DOX整合入脂质功能化金纳米棒实现线粒体靶向协同治疗

发布时间：2025-07-01 作者：kx 分享到：

文献：脂质功能化的金纳米棒与直接插入线粒体的靶向配体用于**的协同光热化疗

链接：https://www.sciencedirect.com/science/article/abs/pii/S0939641123000425

作者：米王，莫张，胡晓晓，王文丽，张耀，张丽娜，王静

摘要：

线粒体靶向*策略有望实现更有效、更精准的癌症*。光热疗法作为一种非侵入性癌症*方法已被广泛研究。对于一体化纳米载体介导的药物递送平台而言，如何在不损害其他优点的情况下增强其中一项特性仍然是一个挑战。在此，我们提出了一种线粒体靶向光热化疗一体化纳米平台，该平台包含脂质功能化的金纳米棒 (AuNR) 和可直接插入线粒体的靶向配体，用于协同增强**。

首先，利用巯基和金的特殊亲和力，用 DSPE-PEG-SH 修饰 AuNR。然后，将具有线粒体靶向特性的 DSPE-PEG-DOX 直接插入 DSPE-PEG-SH 层。同时，将紫杉醇 (PTX) 负载于脂质层的疏水区。与引入额外的线粒体靶向分子不同，我们将两亲性DSPE-PEG-DOX引入到围绕金纳米棒修饰的DSPE-PEG-SH层中，在简单的金纳米棒-脂质-DOX/紫杉醇平台中同时实现线粒体靶向、光热和双载药，从而有效增强线粒体中活性氧（ROS）的产生，并达到*的**效果。基于脂质功能化的金纳米棒构建的纳米平台具有良好的生物相容性，将线粒体靶向的DSPE-PEG-DOX与线粒体作用的紫杉醇和光热疗法（PTT）协同作用，为细胞器靶向的PTT联合化疗以提高疗效提供了一种可行的策略。

Abstract

Mitochondria targeting therapeutic strategies are promising for more effective and precise cancer therapy. Photothermal therapy are extensively studied as noninvasive cancer treatment. With regards to all-in-one nanocarrier-mediated drug delivery platform, it is still a challenge to enhance one of the features but not compromise other merits. Herein, we present a mitochondrial targeting photothermal-chemotherapy all-in-one nanoplatform involving lipid-functionalized gold nanorods (AuNR) with plug-to-direct mitochondria targeting ligand for synergetic enhanced tumor therapy. Firstly, AuNR were modified by DSPE-PEG-SH owing to the special affinity of sulfhydryl group and gold. And then, DSPE-PEG-DOX with mitochondrial targeting character was directly inserted into DSPE-PEG-SH layer. Meanwhile, paclitaxel (PTX) was loaded in hydrophobic region of the lipid layer. Quite different from introducing additional mitochondrial targeting molecules, we incorporated amphiphilic DSPE-PEG-DOX into a DSPE-PEG-SH layer modified around AuNR to achieve both mitochondrial targeting, photothermal and dual drug loading in a simple AuNR-lipid-DOX/PTX platform, in the case that efficiently enhanced production of reactive oxygen species (ROS) in mitochondria and excellent anti-tumor efficacy were achieved. With good biocompatibility, the constructed nanoplatform based on lipid-functionalized AuNR synergistically combined mitochondrial targeted DSPE-PEG-DOX with mitochondrial-acted PTX and photothermal therapy (PTT), which provided a feasible strategy for organelle-targeted combination PTT-chemotherapy to improve therapeutic effects.

DSPE-PEG-DOX