文献：MPEG-DSPE polymeric micelle for translymphatic chemotherapy of lymph node metastasis

作者：Xue Li a 1, Qing Dong a 1, Zhiqiang Yan b, Weiyue Lu a, Lingling Feng c, Cao Xie a, Zuoxu Xie a, Bingxia Su a, Min Liu 

文献链接：https://www.sciencedirect.com/science/article/abs/pii/S0378517315002902

The MPEG-DSPE/DOX micelle prepared were of spherical morphology with a particle size of 20 ± 5 nm. The uptake rates of DOX and MPEG-DSPE/DOX micelle by A375 cells were 51.2% and 88.7%, respectively. The phagocytosis rate of MPEG-DSPE/Rhodamine B micelle by RAW264.7 cells was 17.2-fold lower than for Rhodamine B alone. After subcutaneous injection, MPEG-DSPE micelle underwent lymphatic absorption and accumulated in popliteal lymph nodes. MPEG-DSPE/DOX micelle significantly alleviated damage to the subcutaneous tissue of the injection sites compared with DOX alone. We established a model of nude mice bearing lymph node metastasis of A375 cells. After subcutaneous injection, the weights of both the popliteal and iliac lymph nodes of the MPEG-DSPE/DOX micelle group were significantly lower than in the saline and DOX groups. MPEG-DSPE/DOX micelle effectively killed the tumor cells in popliteal and iliac lymph nodes. 

制备的MPEG-DSPE/DOX胶束呈球形，粒径为20±5nm。A375细胞对DOX和MPEG-DSPE/DOX胶束的摄取率分别为51.2%和88.7%。RAW264.7细胞对MPEG-DSPE/罗丹明B胶束的吞噬率比单独使用罗丹明B低17.2倍。皮下注射后，MPEG-DSPE胶束发生淋巴吸收并积聚在腘淋巴结中。

与单独使用DOX相比，MPEG-DSPE/DOX胶束显著减轻了注射部位皮下组织的损伤。我们建立了携带A375细胞淋巴结转移的裸鼠模型。皮下注射后，MPEG-DSPE/DOX胶束组的腘和髂淋巴结重量均显著低于生理盐水组和DOX组。

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