文献：Preparation, characterization, in vitro, and in vivo assessment of bortezomib-loaded poly (ethylene glycol)-distearyl phosphatidylethanolamine nanomicelles

作者：Hou, Jian PhD; Zong, Zhengtao BS; Zhu, Feng MS; Ge, Yuhong BS; Li, Chunyan MS; Hu, Canhui MS; Chen, Zaixin PhD*

文献链接：https://journals.lww.com/ijsoncology/fulltext/9900/preparation,_characterization,_in_vitro,_and_in.23.aspx

Poly (ethylene glycol)-distearyl phosphatidylethanolamine (mPEG-DSPE) is an amphiphilic block copolymer comprising hydrophilic head and hydrophobic tail. Due to its safety and biocompatibility, it has been approved by the U.S. FDA and extensively used as pharmaceutical excipient in polymeric micellar systems. This application has been extensively reviewed by Wang et al[22], highlighting its biocompatibility, targeting capabilities, and sustained drug release properties. Gill further elucidated the structure-function relationships of PEG-lipid micelles, providing a systematic analysis of their physicochemical determinants, formulation optimization strategies, and biological interactions in targeted delivery systems[23]. In this study, mPEG-DSPE was utilized to formulate BTZ polymer micelles (BTZ/PM), aiming to boost the antitumor activity of the drug during delivery while reducing its toxicity and side effects. 

聚乙二醇-二硬脂基磷脂酰乙醇胺（mPEG-DSPE）是一种两亲性嵌段共聚物，包括亲水性头部和疏水性尾部。

进行了广泛的综述，强调了其生物相容性、靶向能力和持续药物释放特性。Gill进一步阐明了PEG脂质胶束的结构-功能关系，对其物理化学决定因素、制剂优化策略和靶向递送系统中的生物相互作用进行了系统分析。在这项研究中，mPEG-DSPE被用来配制BTZ聚合物胶束（BTZ/PM），旨在提高药物在递送过程中的抗肿瘤活性，同时降低其毒性和副作用。

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