文献：红细胞内化精氨酸-甘氨酸-天冬氨酸(iRGD)修饰增强胃癌放射*疗效

链接：https://pmc.ncbi.nlm.nih.gov/articles/PMC9660045/

作者：周冲 ,刘勤 ,孟凡彦 ,丁乃清 ,景艳 ,刘宝瑞

节选：

采用1,2-二硬脂酰-sn-甘油-3-磷酸乙醇胺-聚乙二醇-iRGD（DSPE-PEG-iRGD）通过脂质插入法修饰红细胞（RBC），无需直接化学生物偶联。通过共聚焦显微镜观察荧光染料示踪功能性红细胞。体外稳定性评估：将红细胞置于细胞培养基中孵育48小时，然后进行荧光衰减试验。此外，构建了MKN-45细胞皮下移植癌细胞小鼠模型，以评估DSPE-PEG-iRGD修饰红细胞（RBC-iRGD）的靶向药效和靶向增强效应。

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-poly ethylene glycol-iRGD (DSPE-PEG-iRGD) was used to modify RBCs by a lipid-insertion method without direct chemical bioconjugation. Fluorescent dyes were used to trace the functional RBCs through confocal microscopy examination. In vitro stability evaluation was performed using cell culture medium incubation for 48 h followed by fluorescence decay assay. Furthermore, a subcutaneous cancer cell mouse model was constructed with MKN-45 cells for target efficacy and RT enhancement evaluation with DSPE-PEG-iRGD-modified RBCs (RBC-iRGD).

西安齐岳生物提供相关产品：

DSPE-PEG-Estrogen

DMPE-PEG-Silane

DSPE-PEG-Pyrene

DSPE-PEG-Silane

DSPE-PEG-Dextran

m-PEG8-DSPE

DSPE-PEG-His

Peptides PEG PCL

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