文献：靶向递送包裹康普瑞塔汀A-4和阿霉素的RGD修饰脂质体用于**：体外和体内研究

链接：https://www.sciencedirect.com/science/article/abs/pii/S0939641110000044

作者：张逸飞，王建成，卞东彦，张 轩 ,张强 

节选：

RGD–PEG-DSPE的合成

DSPE-PEG-RGD 的制备方法如上所述 。对反应混合物在不同时间点的色谱分析（图 1）表明，在反应条件下，RGD 几乎完全消耗。反应体系中约 50% 的 DSPE-PEG-NHS 输入量与 RGD 肽结合。所得产物无需进一步纯化即可用于制备脂质体。

Synthesis of RGD–PEG-DSPE

Preparation of DSPE-PEG-RGD was performed as described previously [12]. Chromatographic analysis of the reaction mixture at different time points (Fig. 1) showed that the RGD was consumed almost completely under the conditions of reaction. Around 50% of input DSPE-PEG-NHS in reaction system was conjugated with RGD peptide. The resulting product was then used for preparing liposomes without further purification.

西安齐岳生物提供相关产品：

DSPE

C18-PEG-COOH

Cy5-DSPE

DSPE-PEG-NPC

DSPE-PEG-TMS

ALC-0315

T7-PEG-PCL

MMPs-PEG-DSPE

DSPE-PEG-Estrogen

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