PEG-生物素自组装纳米粒子在不同 pH 条件下 DOX 控释性能-UDP糖丨MOF丨金属有机框架丨聚集诱导发光丨荧光标记推荐西安齐岳生物

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PEG-生物素自组装纳米粒子在不同 pH 条件下 DOX 控释性能

发布时间：2025-07-15 作者：zyl 分享到：

文献：Biotin-conjugated PEGylated porphyrin self-assembled nanoparticles co-targeting mitochondria and lysosomes for advanced chemo-photodynamic combination therapy†

作者：Baskaran Purushothaman , Jinhyeok Choi , Solji Park , Jeongmin Lee , Annie Agnes Suganya Samson , Sera Hong and Joon Myong Song

文献链接：https://pubs.rsc.org/en/content/articlehtml/2018/tb/c8tb01923a

摘要：

The release pattern of DOX from the DOX@TPP–PEG–biotin self-assembled nanoparticles was evaluated by the dialysis method. In this experiment, the released sample was measured at different time points using HPLC. Fig. 2c shows the release of DOX from the self-assembled nanoparticles at 37 °C in different PBS media (pH 7.4 and pH 6.0), indicating desirable stability of the DOX@TPP–PEG–biotin SANs. After 24 h, the DOX released was only 30.0 ± 1.8% in the pH 7.4 PBS medium compared to that in the pH 6.0 PBS medium (65.4 ± 2.0%). These results indicate that under acidic conditions the DOX was released into the cellular medium. The sizes and zeta potentials in Fig. 2a and b showed no aggregation behavior at room temperature for five days at 37 °C, indicating that the self-assembled nanoparticles prepared in this study showed adequate stability.

DOX@TPP–PEG–biotin

DOX的释放模式DOX@TPP通过透析法对PEG-生物素自组装纳米粒子进行了评估。在该实验中，使用HPLC在不同时间点测量释放的样品。

显示了在37°C下，在不同的PBS介质（pH 7.4和pH 6.0）中，DOX从自组装纳米粒子中释放出来，表明DOX具有稳定性DOX@TPP–PEG–生物素SAN。24小时后，与pH 6.0 PBS培养基（65.4±2.0%）相比，pH 7.4 PBS培养基中释放的DOX仅为30.0±1.8%。

这些结果表明，在酸性条件下，DOX被释放到细胞培养基中。图2a和b中的尺寸和ζ电位在37°C的室温下连续五天没有显示出聚集行为，表明本研究中制备的自组装纳米粒子显示出足够的稳定性。