文献：具有聚集诱导发光的氧化还原敏感聚合物胶束用于生物成像和*癌药物的递送

链接：https://link.springer.com/article/10.1186/s12951-020-00761-9

作者：孙长振,吉禄,王俊,郝平,李春红,陆奇,林杨何斌钟志荣&那好

节选：

mPEG-SAA的合成

将mPEG（0.2 g，0.1 mmol）和SAA（0.05 g，0.5 mmol）溶于60 mL无水二氯甲烷中，剧烈搅拌。冰浴下，将吡啶（0.4 mL）逐滴加入混合物中。室温下搅拌48 h。在搅拌下，向反应体系中加入适量乙酸，以中和体系中生成的盐。过滤除去沉淀，蒸发滤液，将粗品产物沉淀于大量冷乙醚中。重复此纯化步骤数次，得到mPEG-SAA。

Synthesis of mPEG-SAA

The mPEG (0.2 g, 0.1 mmol) and SAA (0.05 g, 0.5 mmol) were dissolved in 60 mL of anhydrous CH2Cl2 with strong stirring. Pyridine (0.4 mL) was added dropwise to the mixture on an ice bath. The mixture was stirred at room temperature for 48 h. An appropriate amount of acetic acid was added to the reaction system under stirring in order to neutralize salts produced in the system. The precipitate was removed by filtration, the filtrate was evaporated and the crude product was precipitated in a large volume of cold diethyl ether. This purification procedure was repeated several times to yield mPEG-SAA.

西安齐岳生物提供相关产品：

DSPE-PEG-GE11(二硬脂酰基磷脂酰乙醇胺-聚乙二醇-*细胞表皮生长因子EGFR靶向肽)

DSPE-PEG-N3

DSPE-PEG-RGD 二硬脂酰基磷脂酰乙醇胺-聚乙二醇-多肽

DSPE-PEG-OX26 mAb（二硬脂酰基磷脂酰乙醇胺-聚乙二醇-*靶向蛋白)

Angiopep-2-PEG-DSPE

以上文章内容来源各类期刊或文献，如有侵权请联系我们删除！