文献：马来酰亚胺官能化聚（ε-己内酯）-嵌段-聚乙二醇（PCL-PEG-MAL）：合成、纳米颗粒形成和硫醇共轭

链接：https://onlinelibrary.wiley.com/doi/abs/10.1002/macp.200900025

作者：吉胜祥， 朱正熙， 托马斯·R·霍伊， 克里斯托弗·W·马科斯科

节选：

合成了具有窄多分散性的羧酸封端的聚（ε-己内酯）（PCL-COOH），并将其与聚（乙二醇）（HO-PEG-OH）偶联，得到PCL-PEG-OH共聚物。然后将PCL-PEG-OH中的羟基转化为马来酰亚胺基团，得到含有70–90％马来酰亚胺官能团的马来酰亚胺封端的PCL-PEG-MAL。通过撞击混合制备了表面具有马来酰亚胺官能团的纳米颗粒。通过动态光散射测定粒径和粒径分布。还证明了还原谷胱甘肽与模型马来酰亚胺和两种MAL官能团纳米颗粒的结合。使用Ellman试剂测量了颗粒表面可及马来酰亚胺的量，范围为≈51–67％。

Abstract

Carboxylic acid terminated poly(ε-caprolactone)s (PCL-COOHs) with narrow polydispersity were synthesized and coupled with poly(ethylene glycol) (HO–PEG–OH) to afford PCL-PEG–OH copolymers. The hydroxyl groups in the PCL-PEG–OHs were then converted to maleimide groups to afford maleimide terminated PCL-PEG-MALs that contained 70–90% maleimide functionality. Nanoparticles with maleimide functionality on their surfaces were prepared by impingement mixing. Particle sizes and size distributions were determined by dynamic light scattering. Conjugation of reduced glutathione with model maleimides and two MAL-functional nanoparticles was also demonstrated. The amount of accessible maleimide on the particle surface was measured using Ellman's reagent to range between ≈51–67%.

西安齐岳生物提供相关产品：

PCL-PEG-Folate

PCL-PEG-Biotin

PCL-Glucose

PCL-g-PEI

PCL-Heparin

PCL-PEG-Heparin

PCL-Galactose

PCL-PEG-Galactose

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