文献：The role of MoS2 QDs coated with DSPE-PEG-TPP in the protection of protein secondary structure of the brain tissues in an Alzheimer's disease model

作者：Ohoud Abdulaziz Alamri a b, Safaa Qusti b, Maha Balgoon b, Abeer A. Ageeli c, F.A. Al-Marhaby d, Abeer M. Alosaimi e, Mohammed A. Jowhari f, Abdu Saeed g 

文献链接：https://www.sciencedirect.com/science/article/abs/pii/S0141813023054211

摘要：

In a recent groundbreaking study [13], a pioneering approach was employed utilizing MoS2 QDs coated with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(poly-ethyleneglycol)-2000] (DPSE-PEG) linked with (3-carboxypropyl)triphenylphosphonium bromide (TPP). This innovative compound, recognized for its novel mitochondria-targeted properties, represents a potential therapeutic avenue for AD treatment [13]. The strategic DSPE-PEG-TPP coating layer serves as an essential interface, facilitating the attachment of MoS2 QDs to the mitochondria of microglia cells within brain tissues. Our present investigation builds upon this paradigm, delving into the intricate role of MoS2 coated with DSPE-PEG-TPP in safeguarding the protein secondary structure within brain tissues. Moreover, a comprehensive exploration of the impact of DSPE-PEG-TPP-MoS2 QDs treatment on a spectrum of biomarkers has been meticulously undertaken. Further elucidation of the methodology, detailed results, and an in-depth analysis can be found in subsequent sections, offering a comprehensive understanding of our study. This study sheds light on the role of MoS2 QD in the protection of the protein secondary structure of the brain tissues against AD etiology.

采用了一种开创性的方法，利用涂有1,2-二硬脂酰基-sn-甘油-3-磷乙醇胺-N-[氨基（聚乙二醇）-2000]（DPSE-PEG）的MoS2量子点，与（3-羧丙基）三苯基溴化鏻（TPP）连接。这种创新化合物因其新颖的线粒体靶向特性而受到认可，代表了阿尔茨海默病的潜在治疗途径。战略性的DSPE-PEG-TPP涂层是一个重要的界面，促进MoS2-QD附着在脑组织内小胶质细胞的线粒体上。

我们目前的研究建立在这一范式的基础上，深入研究了涂有DSPE-PEG-TPP的MoS2在保护脑组织内蛋白质二级结构方面的复杂作用。此外，对DSPE-PEG-TPP-MoS2量子点治疗对一系列生物标志物的影响进行了全面的探索。

在后续章节中可以进一步阐明方法、详细结果和深入分析，从而全面了解我们的研究。本研究揭示了MoS2-QD在保护脑组织蛋白质二级结构免受AD病因影响方面的作用。

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