文献：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy

作者：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie

文献链接：https://onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801

摘要：

considered the cross-coupling reaction between the above cationic carriers and nonionic water-soluble polymers PEG to increase the solubility and decrease aggregation of the composites. Besides that, the combination between CDDP and aldehyde sodium alginate modified SPION is more capable of adsorbing PEG modified PEI via electrostatic interaction due to the improved biocompatibility, water-solubility, and longer circulation time in blood. Meanwhile, the targeting FA-PEG-PEI was prepared by amidation reaction between the carboxyl groups of FA and amino groups of NH2-PEG-OH. Finally, FA-PEG-PEI@SPION-CDDP-TFPI-2 nanocomplex was performed by linking FA-PEG-PEI with SPION-CDDP and CDDP according to appropriate proportion. In vitro assay demonstrated the superiority of the nanocomplex in specific targetability for FR+ tumors.

考虑了上述阳离子载体与非离子水溶性聚合物PEG之间的交叉偶联反应，以提高复合材料的溶解度并减少聚集。此外，由于生物相容性、水溶性和血液循环时间更长，CDDP和醛-海藻酸钠修饰的SPION之间的组合更能通过静电相互作用吸附PEG修饰的PEI。

同时，通过FA的羧基与NH2-PEG-OH的氨基之间的酰胺化反应制备了靶向FA-PEG-PEI。最后，FA-PEG-PEI@SPION-CDDP-TFPI-2通过将FA-PEG-PEI与SPION-CDDP和CDDP按适当比例连接，进行纳米复合物的制备。

体外试验表明，纳米复合物在FR+肿瘤的特异性靶向性方面具有优越性。

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