一系列可裂解接头的 ADC-Linker抗体偶联药物

西安齐岳生物供应带有一系列可裂解的接头（pH接头，二硫键，肽接头，β-葡萄糖苷酸接头），不可裂解的接头和中间接头模块。

什么是抗体偶联药物（ADC）

抗体偶联药物（ADC）是将单克隆抗体的**特异性和靶向性与小分子药物的细胞*性结合成一个新的药物分子，这些分子由三部分组成：单克隆抗体、稳定的连接物以及细胞*性小分子药物。

 ADC是采用特定的连接子将抗体和小分子细胞*药物连接起来的偶联物，抗体分子主要发挥靶向投递作用。

       ADC结构

ADC作用方式：

①循环，ADC药物采用系统暴露的方式给药，。

②结抗原，抗体识别特异性的抗原位点，该过程将决定靶向投递的特异性。

③内化，抗体与细胞膜上受体结合后，发生内吞。

④药物释放，连接子在细胞内溶酶体中裂解，释放出小分子细胞*药物。

⑤发挥药物作用，小分子细胞*药物发挥作用，损伤**细胞。

                ADC作用机制

西安齐岳生物供应相关产品目录，cas号和产品名称如下：

cas:2183440-72-2 N3-PEG3-NH-PEG3-COOH

cas:2100306-83-8 Alkyne-PEG2-NH-PEG2-alkyne

cas:2182601-69-8 Boc-PEG-NH-PEG-Boc (PEG1-PEGn)

cas:123852-08-4 Methyl-PEG-NH-PEG-methyl (PEG1-PEGn)

cas:1964503-36-3 t-butyl ester-PEG-NH-PEG-t-butyl ester (PEG1-PEGn)

cas:275385-03-0 HO-PEG-Boc-PEG-OH (PEG1-PEGn)

cas:2054339-01-2 HOOC-PEG-Boc-PEG-COOH (PEG1-PEGn)

cas:2100306-79-2 N3-PEG-Boc-PEG-N3 (PEG1-PEGn)

cas:2055042-31-2 NHS ester-PEG3-Boc-PEG3-NHS ester

cas:2086689-01-0 2086689-01-0

cas:2093153-85-4 N3-PEG-Boc-PEG-NHS ester (PEG1-PEGn)

cas:2093153-07-0 N3-PEG-Boc-PEG-t-butyl ester (PEG1-PEGn)

cas:2100306-85-0 Hydroxy-PEG1-Boc-PEG2-alkyne

cas: 2093152-78-2 Alkyne-PEG2-Boc-PEG3-t-butyl ester

cas:2128735-20-4 Amine-PEG2-Mal-PEG2-amine

cas:2110449-02-8 Acid-PEG2-Mal-PEG2-acid

cas:2182601-73-4 NHS ester-PEG2-Mal-PEG2-NHS ester

cas:2128735-22-6 Amine-PEG2-Mal-PEG2-amine

cas:2128735-26-0 NH-Boc-PEG2-Mal-PEG2-NH-Boc

cas:2100306-51-0 t-butyl ester-PEG2-Mal-PEG2-t-butyl ester

cas:342818-95-5 Hydroxy-PEG2-N-methyl-PEG2-Hydroxy

cas:2055014-77-0 Acid-PEG4-N-methyl-PEG4-acid

cas:1835759-84-6 Alkyne-PEG2-N-methyl-PEG2-alkyne

cas:2182601-79-0 Methyl-PEG4-N-OH-PEG4-methyl

cas:1964503-35-2 Acid-PEG4-Biotin-PEG4-acid

cas:2100306-84-9 Amine-PEG4-Biotin-PEG4-acid

cas:2112731-59-4 N3-PEG2-Biotin-PEG3-acid

cas:2353409-72-8 DBCO-PEG4-Biotin-PEG4-NHS ester

cas:2055041-21-7 Acid-PEG4-S-PEG4-acid

cas:2055023-77-1 N3-PEG3-S-PEG3-N3

cas:2055041-24-0 N3-PEG3-S-PEG4-alkyne

cas:2055041-19-3 N3-PEG3-S-PEG4-t-butyl ester

cas:2173095-09-3 Methyl-PEG3-S-PEG2-hydroxy

cas:2055040-85-0 Methyl-PEG3-S-PEG4-alkyne

cas:2055040-96-3 Methyl-PEG3-S-PEG3-t-butyl ester

cas:2055041-20-6 Acid-PEG4-S-PEG4-alkyne

cas:2055041-17-1 Alkyne-PEG4-S-PEG4-alkyne

cas:2055041-18-2 Alkyne-PEG4-S-PEG4-t-butyl ester

cas:2055024-37-6 Acid-PEG4-Sulfone-PEG4-acid

cas:2055024-42-3 N3-PEG3-Sulfone-PEG4-acid

cas:2055024-45-6 N3-PEG3-Sulfone-PEG3-N3

cas:2055023-76-0 N3-PEG3-Sulfone-PEG4-t-butyl ester

cas:1919045-04-7 Methyl-PEG3-Sulfone-PEG3-acid

cas:1895922-76-5 Methyl-PEG3-Sulfone-PEG3-N3

cas:1919045-00-3 Methyl-PEG3-Sulfone-PEG2-hydroxy

cas:2055041-02-4 Methyl-PEG3-Sulfone-PEG4-alkyne

cas:2055041-00-2 Methyl-PEG3-Sulfone-PEG3-t-butyl ester

cas:2055024-41-2 Alkyne-PEG4-Sulfone-PEG4-acid

cas:2055041-02-4 Methyl-PEG3-Sulfone-PEG4-alkyne

cas:2055041-00-2 Methyl-PEG3-Sulfone-PEG3-t-butyl ester

cas:2055024-41-2 Alkyne-PEG4-Sulfone-PEG4-acid

cas:229977-57-5 MAC glucuronide linker-2

cas:791028-27-8 Amino-PEG2-C2-acid

cas:55750-61-3 AMAS

cas:1263044-56-9 MC-PEG2-C2-NHS ester

cas:185022-12-2 Aminooxy-PEG2-alcohol

cas:882847-34-9 Fmoc-NH-PEG6-CH2CH2COOH

cas:1061569-06-9 Ald-Ph-amido-PEG2

cas:132178-37-1 Propargyl-C1-NHS ester

cas:1807503-88-3 THP-SS-PEG1-Boc

cas:875770-32-4 Propargyl-PEG4-Tos

cas:2055014-98-5 Acid-PEG3-SS-PEG3-acid

cas:2182601-68-7 DBCO-PEG4-DBCO

cas:2110448-97-8 Gly-PEG3-amine

cas:1599440-15-9 MC-Gly-Gly-Phe

cas:1599472-25-9 Mal-PEG6-NHS ester

cas:331242-61-6 N-Boc-PEG6-alcohol

cas:1008402-79-6 Bis-PEG9-NHS ester

cas:876345-13-0 Boc-NH-PEG4-CH2COOH

cas:1002342-83-7 Ald-CH2-PEG3-azide

cas:1884578-00-0 Boc-Val-Ala-PAB-PNP

cas:1286837-77-1 trans-Sulfo-SMCC

cas:1309460-27-2 Ald-Ph-amido-PEG4-C2-acid

cas:2101206-86-2 SPDMV-sulfo

cas:1391914-41-2 Propargyl-PEG1-SS-alcohol

cas:1395786-30-7 DBCO-Maleimide

cas:67319-28-2 m-PEG3-CH2CH2COOH

cas:27425-92-9 m-PEG10-alcohol

cas:1257063-35-6 Azido-PEG4-C2-acid

cas:2101206-21-5 Ald-Ph-amido-PEG3-C2-Pfp ester

cas:1415328-95-8 NHPI-PEG4-C2-NHS ester

cas:1347760-82-0 Propargyl-PEG3-acid

cas:1353012-00-6 N3-PEG4-C2-Pfp ester

cas:1807518-67-7 Bromoacetamido-PEG4-acid

cas:635287-26-2 Fmoc-NH-PEG5-CH2COOH

cas:955094-26-5 Mal-amido-PEG2-NHS ester

cas:881895-59-6 6-O-2-Propyn-1-yl-D-galactose

cas:178685-33-1 Azide-PEG3-Tos

cas:1043426-13-6 Aminooxy-PEG2-azide

cas:2055041-39-7 Mal-PEG4-Val-Cit-PAB-OH

cas:1007215-94-2 Ald-Ph-amido-PEG3-C1-Boc

cas:1116086-09-9 Fmoc-Phe-Lys(Trt)-PAB-PNP

温馨提示：西安齐岳生物科技有限公司供应的产品仅用于科研，不能用于人体。