产品名称：

Corynoline，18797-79-0

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

温馨提示：仅用于科研，不能用于人体实验！

Corynoline is an isoquinoline alkaloid that has been found in C. incisa and has diverse biological activities.1,2,3,4,5 It is an inhibitor of acetylcholinesterase (IC50 = 30.6 µM) and β-secretase 1 (BACE1; IC50s = 33.59 and 89.07 µM for FRET and immobilized enzyme reactive assays, respectively).1,2 Corynoline (1-4 µM) decreases LPS-induced NF-κB activation and further increases LPS-induced increases in Nrf2 and heme oxygenase-1 (HO-1) protein levels in human umbilical vein endothelial cells (HUVECs).3 It increases the survival rate in a mouse model of LPS- and heat-killed E. coli-induced sepsis when administered at doses of 10, 20, and 40 mg/kg.4 Corynoline selectively inhibits proliferation of B16/F10 mouse and A375 human melanoma cells (IC50s = 12.87 and 10.47 µM, respectively) over non-cancerous melanocytes (IC50 = 126.61 µM).5 It halts the cell cycle at the G2 phase and induces apoptosis and the production of reactive oxygen species (ROS) in a dose-dependent manner in the same cells. It also reduces tumor growth in a B16/F10 mouse melanoma model when administered at a dose of 20 mg/kg.

相关产品：

Plumbagin，481-42-5，5-hydroxy-2-methyl-1,4-naphthalenedione

Nitrotyrosine Polyclonal Antibody，3-Nitrotyrosine

Nitrotyrosine Monoclonal Antibody - Biotinylated，3-Nitrotyrosine

编辑：XAQYBIO HAO，2023年3月15日。