产品名称：

3-AP，143621-35-6

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

温馨提示：仅用于科研，不能用于人体实验！

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.1 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity.2 At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair.2 It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species.3 Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.4

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编辑：XAQYBIO HAO，2023年3月15日。