产品名称：

Disulfiram-d20，1216403-88-1

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

温馨提示：仅用于科研，不能用于人体实验！

Disulfiram-d20 is intended for use as an internal standard for the quantification of disulfiram (Item No. 15303) by GC- or LC-MS. Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM).1 It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine.2 When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells.3,4 Disulfiram (at 250 nM) induces reactive oxygen species, activates JNK and p38 pathways, and inhibits NF-κB activity, which suppresses self-renewal in cancer stem cells.5,6

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编辑：XAQYBIO HAO，2023年3月15日。