产品名称：

活性氧GPX4 Polyclonal Antibody，Glutathione Peroxidase 4，GSHPx-4，PhGPx

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

温馨提示：仅用于科研，不能用于人体实验！

Glutathione peroxidase 4 (GPX4) is a selenocysteine-containing glutathione peroxidase that is encoded by the GPX4 gene in humans and protects cellular membranes from oxidative damage.1,2 It is a monomeric protein consisting of a thioredoxin motif and a selenocysteine-glutamine-tryptophan catalytic triad that reduces lipid hydroperoxides, including phospholipid, polyunsaturated lipid, and sterol hydroperoxides, to non-toxic lipid alcohols. During this process, the active site selenocysteine becomes oxidized and must subsequently be replenished by the reducing substrate glutathione (GSH).2 There are three isoforms of GPX4, mitochondrial mGPX4, cytosolic cGPX4, and nuclear nGPX4/snGPX4, that are expressed in all tissue types in rats, with the highest mRNA levels observed in testes.1,2,3 GPX4 is a key regulator of ferroptosis that inhibits ferroptotic cell death by preventing iron-dependent accumulation of toxic lipid reactive oxygen species.2 Mutations in GPX4 have been found in patients with Sedaghatian-type spondylometaphyseal dysplasia (SSMD), and silencing of Gpx4 in mice is embryonic lethal.4,2 Cayman's GPX4 Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes GPX4 at 20 kDa from human, mouse, rat, and porcine samples.

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编辑：XAQYBIO HAO，2023年3月15日。