Angiopep-2，19个氨基酸组成的胶质瘤靶向肽

产品名称：Angiopep-2

CAS:  N/A

中文名称：19个氨基酸组成的胶质瘤靶向肽

英文名称：Angiopep-2

分子量: 2301.47

存储条件：-20°干燥避光，惰性气体保护

溶解度：溶于有机溶剂

用途:科研

产地:西安

供应商：西安齐岳生物科技有限公司

注意事项:仅用于科研不用于人体

描述：

Angiopep-2（Ang）是Angiopeps家族中的一种人工肽，可以通过低密度脂蛋白受体相关蛋白（low-density lipoprotein receptor-related protein，LRP）受体介导跨越BBB，常应用于修饰脑靶向递药系统，增强BBB穿透率

Angiopep-2 is a peptide that has gained attention in the field of drug delivery and targeted therapy for various diseases, including brain diseases. It is derived from a natural protein called Kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 (TFPI-2).

Angiopep-2 is known for its ability to cross the blood-brain barrier (BBB), which is a protective barrier that prevents many substances from entering the brain. By bypassing this barrier, Angiopep-2 allows for the delivery of therapeutic agents directly into the brain, making it a promising tool for the treatment of brain disorders.

Researchers have explored the use of Angiopep-2 for delivering chemotherapy drugs, nanoparticles, and other therapeutic agents to the brain. Its specificity for brain delivery makes it a potential strategy for targeting brain tumors, neurodegenerative diseases, and other neurological conditions.

However, it's important to note that while Angiopep-2 shows promise as a targeted drug delivery system, further research and development are still required to fully understand its potential therapeutic applications and optimize its effectiveness.

Angiopep-2是一种多肽分子，被广泛研究用于将药物运输到脑部。它由19个氨基酸组成，它的序列是Arg-Gly-Asp-Phe-Val-Val-Asp-Val-Tyr-Ile-His-His-Arg-Ile-Leu-Gln-Arg-His-Phe（RGD的两个氨基酸序列），它具有高度选择性和亲和力，可与血脑屏障上的脑血管内皮细胞结合。

Angiopep-2通过其与低密度脂蛋白受体相关蛋白1（LRP1）的结合，促进药物跨越血脑屏障，并将其输送到脑部。这意味着通过结合Angiopep-2，药物可以更容易地进入脑细胞，从而提高脑部药物的效果。

由于Angiopep-2具有针对血脑屏障的专一性，它已被用于将多种药物（如化疗药物、抗体、肽）输送到脑部，以中枢神经系统疾病，如脑、脑血栓和神经退行性疾病等。

总的来说，Angiopep-2是一种有潜力的载体分子，可通过与LRP1的相互作用，在药物运输到脑部方面具有重要的应用前景。