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抗体药物偶联物(ADC)的抗体靶点/连接臂的选择条件
发布时间:2020-07-06     作者:axc   分享到:

抗体药物偶联物(ADC)的抗体靶点/连接臂的选择条件

西安齐岳生物提供不同结构和功能的多种连接子,可用于抗体和药物的偶联的连接子。我们可以将药物可控地偶联到抗体上,

抗体偶联药物(Antibody–drug conjugates (ADCs))可以定义为药物前体,抗体能够识别表达**抗原的靶点,并通过连接子与细胞*素的“弹头”偶联形成针对**细胞的靶向递送系统。

 

一个理想的ADC药物需要四个部分结合:

抗体(靶点)的选择:针对**特异(相关)性抗原,较高的表达水平,良好的内吞效率、良好的抗原亲和力、无免疫原性、药物可及性;

连接臂的选择:血液循环中保持稳定,在细胞内快速解体,释放*物;

连接方式:定点偶联,产生均一的抗体偶联物;

*素分子:一般要求*素足够强,达到单使用使IC50<1nmol;足够的水溶性及血清中的稳定性;*物的作用靶点位于细胞内。

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抗体偶联药物结构模式

 

齐岳生物为客户提供不同规模的, 用于概念验证(POC)的抗体药物偶联物快速偶联服务。我们使用细胞*素,链接子和偶联方法的提供定制抗体药物偶联物服务。包括全面完整的抗体药物偶联物分析报告

擅长于Seattle Genetics方法偶联

基于半胱氨酸

擅长于Immunogen方法偶联

基于赖氨酸

提供完整的抗体药物偶联物表征分析方法:

分析工具:HPLCHICSECRP),iCIEFLC-MS

质量:药物与抗体比(DAR),通过SDS-PAGE分析的纯度,多聚体,内*素,药物残留

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齐岳生物供应抗体偶联药物连接子目录:

产品名称

产品cas

Fmoc-Val-Cit-PAB

CAS:cas:159858-22-7

Fmoc-Val-Cit-PAB-PNP

CAS:cas:863971-53-3

Val-cit-PAB-OH

CAS:159857-79-1

Phe-Lys(Trt)-PAB

CAS:1116085-99-4

Fmoc-Phe -Lys(Trt)-PAB-PNP

CAS:1116086-09-9

Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP

CAS:253863-34-2

Cbz‐Phe‐(Alloc)Lys‐PAB‐PNP

CAS:159857-90-6

Boc‐Phe‐(Alloc)Lys‐PAB‐PNP

CAS:1160844-44-9

N-SMP

CAS:55750‐61‐3

GMBS

CAS:80307-12-6

5-Maleimidovalericacid-NHS

CAS:103750-03-4

Mal-PEG4-NHS

CAS:1325208-25-0

Mal-PEG-NHS

CAS:1260092-50-9

5-hexynoic NHS ester

CAS:906564-59-8

NHS-PEG4-azide

CAS:944251-24-5

Bis-PEG1-NHS ester

CAS:65869-64-9

Bis-PEG2-NHS Ester

CAS:65869-63-8

Bis-PEG3-NHS Ester

CAS:1314378‐16‐9

NHS-PEG3-NHS

CAS:1314378-11-4

sulfo-LC-SPDP

CAS:150244‐18‐1

MAL-Tetra-EG-OPFP

CAS:1347750-84-8

Mal-PEG5-NHS

CAS:1315355-92-0

Mal-amido-PEG6-NHS

CAS:1137109-21-7

Maleimide-PEG8-NHS ester

CAS:756525-93-6

NHS-Ac-N3

CAS:824426-32-6

NHS-PEG12-azide

CAS:1610796-02-5

Bis-PEG5-NHS ester

CAS:756526-03-1

Bis-PEG9-NHS ester

CAS:1008402-79-6

Boc-Val-Cit-PAB-PNP

CAS:870487-10-8

Alkyne-PEG-acid (PEG1-PEGn)

CAS:55683-37-9

Alkyne-PEG-NHS ester (PEG1-PEGn)

CAS:1174157-65-3

Alkyne-PEG-t-butyl ester (PEG1-PEGn)

CAS:488150-84-1

Alkyne-PEG-alcohol (PEG1-PEGn)

CAS:3973-18-0

Alkyne-PEG-bromide (PEG1-PEGn)

CAS:203740-63-0

Alkyne-PEG-Alkyne (PEG1-PEGn)

CAS:40842-04-4

Alkyne-PEG2-methylamine

CAS:1835759-76-6

Alkyne-PEG4-thiol

CAS:1347750-80-4

Alkyne-PEG4-5-nitrophenyl carbonate

CAS:1422540-81-5

Alkyne-PEG-methane (PEG1-PEGn)

CAS:89635-82-5

Alkyne-PEG4-(CH2)3-methyl ester

CAS:1872433-63-0

APN-C3-PEG4-alkyne

CAS:2183440-36-8

Alkyne-PEG2-acrylate

CAS:52436-42-7

Gly-PEG3-endo-BCN, TFA salt

CAS:2354291-37-3

Boc-Gly-PEG3-endo-BCN

CAS:2110444-63-6

Aminoethyl-SS-ethylalcohol

CAS:15579-01-8

Aminoethyl-SS-propionic acid

CAS:15579-00-7

Aminoethyl-SS-ethylamine

CAS:51-85-4

t-Boc-Cystamine

CAS:485800-26-8

N3-SS-PEG2-acid

CAS:2144777-72-8

N3-SS-propionic NHS ester

CAS:2243566-44-9

N3-SS-ethylalcohol

CAS:1807540-82-4

N3-SS-N3

CAS:352305-38-5

N3-PEG3-SS-PEG3-N3

CAS:1310827-27-0

N3-PEG2-t-Butyl ester

CAS:2144777-83-1

Alkyne-PEG1-SS-alcohol

CAS:1391914-41-2

Alkyne-PEG1-SS-PEG1-acid

CAS:1807503-85-0

Alkyne-PEG1-SS-PEG1-PFP ester

CAS:1817735-30-0

Alkyne-PEG1-SS-PEG1-Alkyne

CAS:1964503-40-9

Alkyne-PEG1-SS-PEG1-t-butyl ester

CAS:1807518-78-0

Acid-PEG-SS-PEG-acid (PEG1-PEGn)

CAS:1807539-10-1

Boc-NH-ethyl-SS-propionic acid

CAS:485800-27-9

Boc-aminooxy-ethyl-SS-propanol

CAS:2128735-21-5

Fmoc-NH-ethyl-SS-propionic acid

CAS:864235-83-6

Fmoc-NH-ethyl-SS-propionic NHS ester

CAS:2128735-23-7

Mal-NH-ethyl-SS-propionic acid

CAS:2128735-24-8

Hydroxy-PEG3-SS-PEG3-alcohol

CAS:5662-81-7

THP-SS-alcohol

CAS:877864-04-5

THP-SS-PEG1-t-butyl ester

CAS:1807503-88-3

THP-SS-PEG1-Tos

CAS:1807512-37-3

2-hydroxyethyl disulfide mono-Tosylate

CAS:1807530-16-0

Bis-Tos-(2-hydroxyethyl disulfide)

CAS:69981-39-1

N3-SS-biotin

CAS:1620523-64-9

DBCO-SS-PEG3-biotin

CAS:1430408-09-5

Biotin-bisamido-SS-NHS

CAS:142439-92-7

NHS-SS-biotin

CAS:122266-55-1

Sulfo-NHS-SS-biotin

CAS:325143-98-4

PC Biotin-PEG3-alkyne

CAS:1869922-24-6

PC Biotin-PEG3-N3

CAS:1937270-46-6

PC Biotin-PEG3-NHS carbonate ester

CAS:2353409-93-3

PC Alkyne-PEG4-NHS carbonate ester

CAS:1802907-98-7

PC Methyltetrazine-PEG4-NHS carbonate ester

CAS:1408057-91-9

PC N3-PEG11-NHS carbonate ester

CAS:2353409-91-1

Mal-PEG2-Val-Cit-PAB-OH

CAS:2055041-38-6

Mal-PEG1-Val-Cit-PAB-PNP

CAS:2249935-92-8

Mal-amido-PEG2-Val-Cit-PAB-PNP

CAS:2112738-13-1

N3-PEG3-Val-Cit-PAB-OH

CAS:2055024-65-0

N3-PEG3-Val-Cit-PAB-PNP

CAS:2055047-18-0

BCN-PEG3-VC-PFP Ester

CAS:2353409-45-5

Methylamino-PEG-acid (PEG1-PEGn)

CAS:1367918-21-5


厂家:西安齐岳生物科技有限公司

温馨提示:西安齐岳生物科技有限公司供应的所有产品仅用于科研,不能用于人体。

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