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肽保护的惰性侧链氨基酸Fmoc-Val-Wang resin树脂
发布时间:2020-07-06     作者:axc   分享到:

肽保护的惰性侧链氨基酸Fmoc-Val-Wang resin树脂

西安齐岳生物科技有限公司是我国较早生产离子交换树脂的厂家。有着多年的生产经验,我公司的产品生产工艺**,质量可靠,广泛用于水处理,化工催化,冶金、提纯、制药,食品工业等。目前已和国内40多个省市的客户建立了业务关系,产品远销俄罗斯、美国、日本、韩国、印度等。   

 

根据合成肽时侧链的活性,可把自然界中 20 种氨基酸分为惰性侧链氨基酸(如:GlyLeuIleAlaVal Phe 等)和活泼侧链氨基酸(如:侧链羧基、侧链氨基、侧链硫醇基和侧链杂环基等)。前一类只需保护 α-氨基,后一种氨基酸还需保护侧链活泼基团。由于主链保护基在接肽时脱去,侧链保护基在接肽后脱去,因此这两种保护基必需具有不同的脱去条件。

结构式:

 image.png

【应用】

Fmoc-甘氨酸为Fmoc保护的甘氨酸,主要用于合成多肽,氨基酸保护基的不同对多肽合成的效率和产率有很大的影响。如Fmoc-甘氨酸可以用于制备一种甘氨酸衍生物缓蚀剂,通过酰胺化反应在甘氨酸分子上接入Fmoc-保护基团和疏水长链,通过杂原子(NO等或不饱和键)和含π电子的双苯环吸附于金属,疏水长链阻挡水分 子,使其在钢铁表面形成一道保护膜,达到防腐的目的。

 

【合成】

甘氨酸是简单的氨基酸,在固相合成中,要把氨基保护起来才能接肽。用 Fmoc-Cl 10%碳酸钠溶液和二氧六环条件下,低温与甘氨酸反应,可制得Fmoc-甘氨酸。实验过程中用薄层色谱监控反应进度,T.L.C 展开剂为:V(Et OH)V(CHCl3)13,试验方程式如下:    

 image.png

Fmoc-甘氨酸合成具体步骤如下:

3.0g 甘氨酸溶解于115ml 10Na2CO3中,冷却到-40℃11.2g Fmoc-Cl 溶解于 35.0ml 丙酮滴加到体系中,滴加完毕,冰浴搅拌30min,然后室温搅拌2.0h

用薄层色谱监控反应进度,反应完毕,倒入400ml水中,乙醚萃取两次,冷却并用浓盐酸调节 pH2 左右,析出大量白色固体,

50 ml乙酸乙酯萃取三次,无水硫酸镁干燥,减压蒸馏除去溶剂,用石油醚析出,得到 11.5g Fmoc-甘氨酸。提纯后,**液相色谱测得产品纯度为97.3

 

产品目录:

Fmoc-Val-Wang resin  100-200 mesh, 1% DVB

Fmoc-Gly-Wang resin  100-200 mesh, 1% DVB

Dilauryl thiodipropionate 100-200 mesh, 1% DVB

Amberlyst 15(H) ion-exchange resin 100-200 mesh, 1% DVB

Amberlite IR 120 100-200 mesh, 1% DVB

Na form, ion-exchange resin 100-200 mesh, 1% DVB

2-Chlorotrityl Chloride Resin 100-200 mesh, 1% DVB

Fmoc-Cys(Trt)-Wang resin 100-200 mesh, 1% DVB

Polystyrene A-RAM 100-200 mesh, 1% DVB

Phenol-formaldehyde resin 100-200 mesh, 1% DVB

Merrifield resin 100-200 mesh, 1% DVB

Rink Amide MBHA 100-200 mesh, 1% DVB

Maleic anhydride-phthalic anhydride-diethylene glycol polymer

Rink Amide AM Resin 100-200 mesh, 1% DVB

Fmoc-Asp(OtBu)-2-Chlorotrityl Resin  100-200 mesh, 1% DVB

 H-Ala-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Threoninol(tBu) DHP HM Resin 100-200 mesh, 1% DVB

DHP HM Resin 100-200 mesh, 1% DVB

H-Thr(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Phe(4-F)-Wang resin 100-200 mesh, 1% DVB

Fmoc-Asp-OAll-Wang resin  100-200 mesh, 1% DVB

Fmoc-Lys(Boc)-2-Chlorotrityl Resin  100-200 mesh, 1% DVB

Fmoc-D-Pro-Wang resin 100-200 mesh, 1% DVB

H-Ala-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Asp-OAll-Wang resin 100-200 mesh, 1% DVB

Fmoc-D-Pro-Wang resin  100-200 mesh, 1% DVB

Fmoc-Arg(Pbf)-2-Chlorotrityl Resin  100-200 mesh, 1% DVB

H-Trp-2-Chlorotrityl Resin  100-200 mesh, 1% DVB

Fmoc-Asp(OtBu)-Tcp Resin 100-200 mesh, 1% DVB

Fmoc-Lys(Dde)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

H-D-Tyr(tBu)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

H-Gln(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

H-Ser(tBu)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-D-Bip-Wang Resin 100-200 mesh, 1% DVB

Dowex 1x8 200-400 exchange resin 100-200 mesh, 1% DVB

Wang Resin 100-200 mesh, 1% DVB

Fmoc-Met-Wang resin 100-200 mesh, 1% DVB

Fmoc-D-Ala-Wang resin 100-200 mesh, 1% DVB

H-Asn-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-D-Phe-Wang resin 100-200 mesh, 1% DVB

Fmoc-Lys(Z)-Wang resin 100-200 mesh, 1% DVB

Fmoc-D-Asn(Trt)-Wang resin 100-200 mesh, 1% DVB

H-Lys(Boc)-Rink Amide AM Resin 100-200 mesh, 1% DVB

Fmoc-Ile-Wang resin 100-200 mesh, 1% DVB

Fmoc-Orn(Boc)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

H-Phe-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Arg(Pbf)-Tcp Resin 100-200 mesh, 1% DVB

Fmoc-Bpa-Wang Resin 100-200 mesh, 1% DVB

Fmoc-Leu-Tcp Resin 100-200 mesh, 1% DVB

 H-Glu-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-His(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Trp(Boc)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Lys(Ivdde)-Wang resin 100-200 mesh, 1% DVB

H-Pro-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

"H-Asp(OtBu)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB


货号:BD302494H-Asp(OtBu)-2-Chlorotrityl Resin 100-200 mesh, 1%"

Fmoc-D-Val-Wang resin 100-200 mesh, 1% DVB

H-Tyr(tBu)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Leu-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Hydroxymethyl Resin 100-200 mesh, 1% DVB

H-Cys(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-N-Me-D-Phe-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-2-Nal-Wang resin 100-200 mesh, 1% DVB

Rink Amide-AM Resin 100-200 mesh, 1% DVB

H-Tyr(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Trp(Boc)-Wang resin 100-200 mesh, 1% DVB

Fmoc-Asn(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Arg(Pbf)-Wang resin 100-200 mesh, 1% DVB

H-Lys(Boc)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Thr-Wang resin 100-200 mesh, 1% DVB

Weinreb AM Resin 100-200 mesh, 1% DVB

Fmoc-Pra-Wang Resin 100-200 mesh, 1% DVB

H-Trp(Boc)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-D-Gln(Trt)-Wang resin 100-200 mesh, 1% DVB

Fmoc-Ser(tBu)-Rink Amide AM Resin 100-200 mesh, 1% DVB

H-β-Ala-2-Chlorotrityl Resin 100-200 mesh, 1% DVB

Fmoc-Pro-Wang resin

Fmoc-Gly-Wang resin

Fmoc-Arg(Pbf)-Wang resin

Fmoc-Phe-Wang resin

Fmoc-Trp(Boc)-Wang resin

Fmoc-Asn(Trt)-Wang resin

Fmoc-Leu-Wang resin

Rink Amide-MBHA Resin

Fmoc-Tyr(Bzl)-Wang Resin

Fmoc-Gln(Trt)-Wang resin

Wang resin

Fmoc-Ala-Wang resin

Fmoc-D-Dab(Boc)-OH

Fmoc-Gly-Rink Amide AM Resin

H-Trp(Boc)-2-Chlorotrityl Resin

6-Chloro-L-Tryptophan

2-Chlorotrityl Chloride Resin

Aminomethyl Polystyrene Resin

Sieber Amide Resin

Rink Amide-AM Resin

Trityl chloride

H-Ile-2-Chlorotrityl Resin

H-Gly-2-Chlorotrityl Resin

Fmoc-Ser(tBu)-Wang resin

Fmoc-Asn(Trt)-OH

Boc-Tyr-OtBu

Fmoc-Hyp(tBu)-OH

Fmoc-Phe(2-F)-OH

Fmoc-Val-OH

Fmoc-D-Ala-NH2

Fmoc-N-Me-Ala-OH

Fmoc-D-Ala-Wang resin

Fmoc-Pen(Acm)-OH

 

 

温馨提示:西安齐岳生物科技有限公司供应的产品仅用于科研,不能用于人体**。


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