常用名 托特罗定

英文名 Tolterodine-L-tartrate

CAS号 124937-51-5

密度 1.0±0.1 g/cm3

沸点 442.2±45.0 °C at 760 mmHg

分子式 C22H31NO

分子量 325.488

闪点 192.1±27.4 °C

精确质量 325.240570

PSA 23.47000

LogP 5.77

蒸汽压 0.0±1.1 mmHg at 25°C

折射率 1.548

储存条件 -20°C Freezer

"Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. 

IC50 Value:

Target: mAChR

in vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM).  The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors [1].

in vivo: Tolterodine was extensively metabolized in vivo [2].  In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased [3]."

包装：100mg，500mg，1g，10g，100g以及kg级别等公斤级大包装

纯度：99%

配送：惯例下常温**

包装：袋装

厂家：西安齐岳生物科技有限公司

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