常用名 托烷司琼

英文名 Tropisetron

CAS号 89565-68-4

密度 1.3±0.1 g/cm3

沸点 448.5±35.0 °C at 760 mmHg

熔点 201-202 °C

分子式 C17H20N2O2

分子量 284.35

闪点 225.0±25.9 °C

PSA 83.80000

LogP 3.55

外观性状 白色固体

蒸汽压 0.0±1.1 mmHg at 25°C

折射率 1.644

储存条件 2-8°C

水溶解性 H2O: soluble

"Tropisetron (SDZ-ICS-930 free base) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. 

IC50 value: 70.1 ± 0.9 nM [1]

Target: 5-HT3 receptor

in vitro: Tropisetron specifically inhibited both IL-2 gene transcription and IL-2 synthesis in stimulated T cells. tropisetron inhibited both the binding to DNA and the transcriptional activity of NFAT and AP-1. We also observed that tropisetron is a potent inhibitor of PMA plus ionomycin-induced NF-(kappa)B activation but in contrast TNF(alpha)-mediated NF-(kappa)B activation was not affected by this antagonist [2]. Tropisetron prevents the phosphorylation and thus activation of the p38 MAPK, which is involved in post-transcriptional regulation of various cytokines [3].

in vivo: Two different doses of tropisetron (5 and 10 mg/kg) or vehicle were administered intraperitoneally 30 min before pMCAO. Neurological deficit scores, mortality rate and infarct volume were determined 24 h after permanent focal cerebral ischemia [4]."

包装：100mg，500mg，1g，10g，100g以及kg级别等公斤级大包装

纯度：99%

配送：惯例下常温**

包装：袋装

厂家：西安齐岳生物科技有限公司

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