常用名 盐酸奥洛他定

英文名 Olopatadine Hydrochloride

CAS号 140462-76-6

密度 1.221 g/cm3

沸点 523ºC at 760mmHg

熔点 242-245ºC

分子式 C21H24ClNO3

分子量 373.873

闪点 270.1ºC

精确质量 373.144470

PSA 49.77000

LogP 4.39150

外观性状 白色固体

蒸汽压 9.65E-13mmHg at 25°C

储存条件 Refrigerator

"Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis.

Target: Histamine Receptor

Olopatadine hydrochloride (ALO4943A) is one of the second-generation histamine H1 receptor antagonists that are treated for allergic disorders. 

Olopatadine hydrochloride (ALO4943A) significantly inhibited the ear swelling and the increased production of IL-4, IL-1beta, IL-6, GM-CSF and NGF in the lesioned ear [1]. 

Olopatadine hydrochloride (ALO4943A) was highly and rapidly absorbed in healthy human volunteers. The urinary excretion of Olopatadine hydrochloride (ALO4943A) accounted for not less than 58% and the contribution of metabolism was considerably low in the clearance of olopatadine in humans. 

Olopatadine hydrochloride (ALO4943A) is one of the few renal clearance drugs in antiallergic drugs. 

Olopatadine hydrochloride (ALO4943A) was shown to be useful for the treatment of allergic rhinitis and chronic urticaria in double-blind clinical trials [2]. 

Olopatadine hydrochloride (ALO4943A) inhibits histamine release in a concentration-dependent fashion (IC50 = 559 microM) from human conjunctival mast cell preparations in vitro. Passive anaphylaxis in guinea pig conjunctiva was attenuated by Olopatadine hydrochloride (ALO4943A) applied 30 min prior to intravenous or topical ocular antigen challenge (ED50 values 0.0067% and 0.0170%, w/v, respectively) [3]."

包装：100mg，500mg，1g，10g，100g以及kg级别等公斤级大包装

纯度：99%

配送：惯例下常温**

包装：袋装

厂家：西安齐岳生物科技有限公司

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