常用名：AZ'6421 

描述：

AZ'6421 充当靶向蛋白水解嵌合体 (PROTAC) 以选择性降解雌激素受体 α。

生物活性

AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha. AZ'6421 has a potent anti-tumour effect to inhibit the uncontrolled cellular proliferation which arises from malignant disease. AZ'6421 can be used for the research of cancer such as breast cancer[1].

IC50 & Target

IC50: 0.6 nM (ER binding); 0.4 nM (ER degradation)[1]

体外研究

(In Vitro)

AZ'6421 (example 72) exhibits anti-tumour activity via the ability to degrade the estrogen receptor in a number of different breast cancer cell-lines (MCF-7, CAMA-I, and BT474)[1].

AZ'6421 (0.3 μM) has ER binding and ER degradation with IC50 values of 0.6 nM and 0.4 nM, respectively in MCF-7 cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AZ'6421 相关抗体:

Estrogen Receptor alpha Antibody (YA768)

Estrogen Receptor alpha Antibody

GPR30 Antibody

pVHL Antibody

FSH receptor Antibody

41701 Antibody (YA1949)

分子量

975.17

Formula

C52H65F3N6O7S

CAS 号

2361115-35-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC（PROteolysis-TArgeting Chimera）是一种异源双功能纳米分子，包含两种不同的配体，一种是用于泛素E3的配体，另一种是用于目标蛋白的配体。这两部分通过连接子连接在一起，形成一个“三单元”聚合物，即目标蛋白配体-连接子-E3连接酶配体。PROTAC分子的构建模块包括PROTAC连接子、用于PROTAC的目标蛋白配体、用于E3连接酶的配体、E3连接酶配体-连接子共轭物、目标蛋白配体-连接子共轭物等。PROTAC技术被广泛应用于药物开发领域，可用于选择性降解特定的蛋白质，具有潜在的治疗应用前景。

产地：西安

用途：科研

厂家：西安齐岳生物科技有限公司

温馨提示：仅用于科研！

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