常用名：2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide

产品描述 2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide (2-3-4-6-tetra-o-acetyl-alpha-galactosylpyranosyl-bromide) is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis.

体外活性 PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

别名 2-3-4-6-tetra-o-acetyl-alpha-galactosylpyranosyl-bromide

分子量 411.2

分子式 C14H19BrO9

CAS No. 529493-92-3

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

PROteolysis TArgeting Chimeras (PROTACs) 通过将靶蛋白和 E3 连接酶结合起来，从而“劫持”细胞的泛素-蛋白酶体系统（UPS）来实现蛋白质的降解。由于 PROTACs 只需具有高选择性地结合其靶标（而不是抑制靶蛋白的酶活性），目前有许多努力将先前无效的抑制剂分子改造为 PROTACs，用作下一代药物。

产地：西安

用途：科研！

厂家：西安齐岳生物科技有限公司

温馨提示：仅用于科研，不能用于人体实验！

相关产品：

CAS: 1984776-37-5

CAS: 2101563-45-3

CAS: 77855-76-6

CAS: 134724-87-1