文献：PLGA-卵磷脂-PEG核壳纳米粒子用于癌症靶向*

链接：https://www.worldscientific.com/doi/abs/10.1142/S1793984411000359

作者：郑明斌， 乒乓球， 贾冬雪， 郑翠芳， 马一帆， 和 蔡林涛

节选：

摘要

我们报道了一种多功能聚乳酸-乙醇酸共聚物 (PLGA)-卵磷脂-聚乙二醇 (PEG) 核壳纳米粒子 (NPs)，该纳米粒子兼具脂质体和聚合物纳米粒子的优点，可用于递送化疗药物。该纳米粒子的粒径、表面电荷和表面官能团可通过各种配方参数轻松调节，且重复性高，例如脂质/聚合物、1,2-二硬脂酰-sn-甘油-3-磷酸乙醇胺 (DSPE)-PEG- COOH /卵磷脂、DSPE-PEG- COOH /DSPE-PEG- NH 2 的质量比以及 DSPE-PEG 端基的修饰。我们将模型化疗药物——亲水性顺铂 (DDP) 或疏水性 DDP 前药——封装于纳米颗粒 (NP) 中，结果显示其包封率高、稳定性佳、对高 FA 受体表达的 MCF-7 细胞具有特异性靶向识别能力，且 FA 受体表达量高，且细胞毒性较小。此类 PLGA-卵磷脂-PEG 核壳纳米颗粒 (NP) 已被证明是一种*具潜力的癌症靶向*药物递送纳米载体。

Abstract

We reported the development of multifunctional poly (lactic-co-glycolic acid) (PLGA)-lecithin-polyethylene glycol (PEG) core-shell nanoparticles (NPs) that combined the beneficial properties of liposome and polymeric NPs for chemotherapeutics delivery. The particle size, surface charge and surface functional groups were easily tunable in highly reproducible manner by various formulation parameters such as lipid/polymer, 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-PEG-COOH/lecithin, DSPE-PEG-COOH/DSPE-PEG-NH2 mass ratio and modification of terminal groups of DSPE-PEG. We encapsulated model chemotherapy drug, hydrophilic cisplatin (DDP) or hydrophobic DDP prodrug, in the NPs and showed high encapsulation efficiency, excellent stability, specific FA targeting recognition for MCF-7 cells with over FA receptors expression and pretty cytotoxicity. Such PLGA–lecithin–PEG core-shell nanoparticles (NPs) were proved to be a promising drug delivery nanocarrier for cancer-targeted therapy.

西安齐岳生物提供相关产品：

DSPE-PEG-PLA

DSPE-PEG-TH

DPPE-PEG-NH2

DSPE-PEG-LTVSPWY（二硬脂酰基磷脂酰乙醇胺-聚乙二醇-*靶向蛋白)

FITC-Angiopep-2-PEG-DSPE

DSPE-Poly(L-lysine)

C18-PEGn-COOH

DSPE(Sodium salt)-PEG-COOH

iRGD-PEG-MAL

DSPE-PEG-NGR

DSPE-PEG-Progestrone

以上文章内容来源各类期刊或文献，如有侵权请联系我们删除！