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DSPE-PEG2000-Biotin修饰DTX脂质体的制备与表征
发布时间:2025-07-16     作者:kx   分享到:

文献:使用磁性纳米探针进行脂质体和非脂质体药物药代动力学研究的快速有效技术及其在脂质体泄漏动力学中的应用

链接:https://www.sciencedirect.com/science/article/abs/pii/S0021967318313086

作者:陈云娜,王雷 ,郭东东 ,陈明盛,戴浩 志 ,小燕 石 ,张文静 ,黄倩倩 ,彭 灿,陈卫东 

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DTX脂质体的表征

本研究采用乙醇注入法制备了含有DSPE-PEG2000-生物素的DTX-脂质体。测定了DTX-脂质体的粒径、PDI和zeta电位,结果如图S1所示。DTX-脂质体的平均粒径、PDI和zeta电位分别为177.2 nm、0.203和-14.7 mV。PDI小于0.3表示脂质体粒径分布均匀。包封率约为98%,载药量约为3.3%。DTX载药脂质体的形态

DSPE-PEG2000-Biotin

Characterization of the DTX-liposomes

In this study, DTX-liposomes with DSPE-PEG2000-biotin were prepared using ethanol injection method. The particle size, PDI and zeta potential of the DTX-liposomes were determined and shown in Fig. S1. The average particle size, PDI and zeta potential of DTX-liposomes were 177.2 nm, 0.203 and −14.7 mV, respectively. The PDI less than 0.3 mean the size of liposomes was distributed uniformly. The encapsulation efficiency was about 98% with loading capacity about 3.3%. The morphology of DTX-loaded

西安齐岳生物提供相关产品:

RGD-PEG-OH

DODAP (18:1)

DSPE-PEG-GRGDS

DSPE-PEG-SCM

DSPE-PEG-Lectins

DSPE-Rhodamine B/DSPE-RhB

DSPE-PEG-Dethiobiotin

DSPE-PEG-Cy3

DSPE-PEG-Glucose

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