文献：聚乳酸-聚乙二醇-聚乳酸三嵌段共聚物的降解性能

作者：高建文，廖凯荣，全大萍，卢泽俭

文献链接：https://xueshu.baidu.com/usercenter/paper/show?paperid=a4591ddfa95725ae7a22a54d2fb088a9&site=xueshu_se

摘要：

A series of polylactic acid (PLA) - polyethylene glycol (PEG) - polylactic acid (PLA) triblock copolymers were prepared by ring opening polymerization of lactide using stannous octoate as initiator and polyethylene glycol as co initiator The influence of PEG molecular weight and propylene ester/PEG molar ratio on the hydrolysis behavior of copolymers was investigated by examining the changes in intrinsic viscosity [η], mass, and thermal behavior of copolymers during hydrolysis in physiological saline The results indicate that PEG blocks have a significant impact on the hydrolysis rate of copolymers When the molar ratio of propylene glycol/PEG is constant, the larger the molecular weight of PEG, the easier it is for the copolymer to hydrolyze; When the PEG block length is constant, the higher the molar ratio of propylene ester/PEG, the slower the hydrolysis rate of the copolymer

以辛酸亚锡为引发剂,聚乙二醇大分子为共引发剂进行丙交酯开环聚合制备了系列聚乳酸(PLA)-聚乙二醇(PEG)-聚乳酸(PLA)三嵌段共聚物.

从共聚物在生理盐水中水解时特性黏度[η],质量和热行为的变化,考察了含PEG分子量和丙交酯/PEG摩尔投料比对共聚物水解行为的影响.

结果表明,PEG嵌段对共聚物的水解速度有重要影响.丙交酯/PEG摩尔投料比一定时,PEG分子量越大,共聚物更容易水解;PEG嵌段长度一定时,丙交酯/PEG摩尔投料比越大,共聚物水解速度比较缓慢.

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mPEG-CH3

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