第一部分：西安齐岳生物微针定制服务核心内容

西安齐岳生物专注于微针递送平台的个性化定制研发，依托自身在纳米载体、材料合成及生物医学工程领域的技术积累，为科研及临床前研究提供全方位、高精准的微针定制服务，核心围绕“材料适配-结构设计-功能优化-应用落地”四大维度，细分以下五大定制方向，兼顾专业性与实用性，全程贴合客户具体需求，实现从实验室设计到规模化制备的全流程定制支持。

第二部分：西安齐岳生物微针定制案例

西安齐岳生物凭借成熟的微针定制技术，已完成多个领域的定制案例，涵盖药物递送、组织修复、靶向*等方向，以下为典型案例详细展示，图文结合呈现定制细节与应用效果。

案例一：ZIF-8@ConA核壳微针贴片

定制需求

武汉大学药学院团队定制一款用于角膜炎*的微针贴片，要求实现*菌与*炎协同*，解决传统滴眼液生物利用度低、*周期长的问题，需具备pH响应性释放能力，确保药物在炎症部位精准释放，同时保证良好的生物相容性与角膜穿透性。

案例二：多肽改性GelMA-ACNM水凝胶微针（组织修复专用）

定制需求

某高校生物医学工程团队定制一款用于皮肤创面修复的水凝胶微针，要求具备良好的生物降解性、细胞黏附性与药物负载能力，可负载生长因子，实现持续释放，促进创面愈合，同时需具备一定的机械强度，确保顺利穿刺皮肤表层。

第三部分：典型高分文献摘抄及翻译

文献一：Fabrication of customized microneedle with high 3D capability and high structural precision

文献基本信息

期刊：Additive Manufacturing（IF=11.2，工程技术领域TOP期刊）；发表时间：2024年；作者：Chen, Zhaolun ; Wang, Zhi ; Jiang, Lan 等（北京理工大学团队）；核心方向：高3D制备能力与高结构精度的定制化微针制备技术研究，为西安齐岳生物3D打印微针定制提供核心技术参考，适配复杂结构微针的定制需求。

核心内容摘抄（英文）

Advanced 3D fabrication techniques are essential for the processing of 3D devices, which mainly focusing on excellent 3D fabrication capability and high structural precision. Although 3D printing technology allows for the creation of complex 3D structures with extensive customization, it faces notable challenges in achieving precise micro/nanostructures within materials due to incomplete resin curing bonds. Here, we propose integrating projection micro-stereolithography (PμSL) with femtosecond (fs) laser Bessel beam drilling to create 3D structures with advanced customization, precise structures (including size accuracy and aspect ratio), and efficient processing. Starting with the drilling process using Bessel beams, we have achieved micro-holes with a diameter of approximately 1μm and the aspect ratio reached 1017:1 on 3D printed items by regulating the transparency and elasticity of the products. Furthermore, we have applied this technology to produce tailor-made microneedles, including slanted-tip microneedles and porous microneedles, demonstrating its ability for extensive, efficient micro-hole processing with a peak drilling speed of 200,000 holes per second. This technology offers an innovative approach to creating three-dimensional devices with intricate cavity structures, and its impressive processing capabilities suggest potential for broad industrial implementation.

核心内容翻译（中文）

先进的3D制备技术是3D器件加工的关键，其核心聚焦于*的3D制备能力和高结构精度。尽管3D打印技术能够实现具有广泛定制性的复杂3D结构，但由于树脂固化键不完全，在材料内部实现精准的微纳结构仍面临显著挑战。本文提出将投影微立体光刻（PμSL）与飞秒（fs）激光贝塞尔光束钻孔技术相结合，制备具有高度定制化、结构精准（包括尺寸精度和长径比）且加工高效的3D结构。通过贝塞尔光束钻孔工艺，我们通过调控产品的透明度和弹性，在3D打印件上实现了直径约1μm的微孔，长径比达到1017:1。此外，我们将该技术应用于定制化微针的制备，包括斜尖微针和多孔微针，证明其具备广泛、高效的微孔加工能力，*高钻孔速度可达每秒200,000个孔。该技术为制备具有复杂腔室结构的三维器件提供了创新方法，其出色的加工能力表明其具有广泛的工业应用潜力。

文献二：Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications

文献基本信息

期刊：PMC（IF=8.5，生物医学领域核心期刊）；发表时间：2025年；核心方向：3D打印技术驱动的定制化微针设计、制备及其生物医学应用进展，为西安齐岳生物微针定制的应用场景拓展、结构设计优化提供理论支撑，覆盖药物递送、生物采样、生物传感等多个定制方向。

核心内容摘抄（英文）

Microneedles (MNs) is an emerging technology that employs needles ranging from 10 to 1000 μm in height, as a minimally invasive technique for various procedures such as therapeutics, disease monitoring and diagnostics. The commonly used method of fabrication, micro molding, has the advantage of scalability, however, micro molding is unable to achieve rapid customizability in dimensions, geometries and architectures, which are the pivotal factors determining the functionality and efficacy of the MNs. 3D printing offers a promising alternative by enabling MN fabrication with high dimensional accuracy required for precise applications, leading to improved performance. Furthermore, enabled by its customizability and one-step process, there is propitious potential for growth for 3D-printed MNs especially in the field of personalized and on-demand medical devices. This review provides an overview of considerations for the key parameters in designing MNs, an introduction on the various 3D-printing techniques for fabricating this new generation of MNs, as well as highlighting the advancements in biomedical applications facilitated by 3D-printed MNs. Lastly, we offer some insights into the future prospects of 3D-printed MNs, specifically its progress towards translation and entry into market.

核心内容翻译（中文）

微针（MNs）是一项新兴技术，其采用高度为10至1000μm的针体，作为一种微创技术应用于*、疾病监测和诊断等多种场景。传统常用的制备方法（微模铸造法）具有可规模化的优势，但无法实现尺寸、几何形状和结构的快速定制，而这些参数是决定微针功能和功效的关键因素。3D打印技术为微针制备提供了一种*具潜力的替代方案，能够实现精准应用所需的高尺寸精度，从而提升微针性能。此外，得益于其定制化能力和一步成型工艺，3D打印微针具有良好的发展潜力，尤其是在个性化和按需医疗设备领域。本文综述了微针设计中关键参数的考量因素，介绍了用于制备新一代微针的多种3D打印技术，并重点阐述了3D打印微针在生物医学应用中的进展。*后，我们对3D打印微针的未来前景进行了展望，特别是其在成果转化和市场应用方面的进展。

第四部分：文献引用链接

1. Aldawood, F.K. et al. (2021). A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications. Polymers. 链接：https://www.mdpi.com/2073-4360/13/16/2815

2. Alfalasi H et al (2025) Hydrogel-based microneedles for the delivery of catalase protein. Int J Pharm. 链接：https://www.sciencedirect.com/science/article/pii/S0378517325003877

3. Amani H et al (2021) Microneedles for painless transdermal immunotherapeutic applications. J Control Release. 链接：https://www.sciencedirect.com/science/article/pii/S016836592030977X

4. Ameri M et al (2010) Parathyroid hormone PTH(1–34) formulation that enables uniform coating on a novel transdermal microprojection delivery system. Pharm Res. 链接：https://link.springer.com/article/10.1007/s11095-009-0019-8

5. Angkawinitwong U et al (2020) A Novel Transdermal Protein Delivery Strategy via Electrohydrodynamic Coating of PLGA Microparticles onto Microneedles. ACS Appl Mater Interfaces. 链接：https://pubs.acs.org/doi/10.1021/acsami.9b22425

6. Chen, Zhaolun ; Wang, Zhi ; Jiang, Lan et al. (2024). Fabrication of customized microneedle with high 3D capability and high structural precision. Additive Manufacturing. 链接：https://pure.bit.edu.cn/en/publications/fabrication-of-customized-microneedle-with-high-3d-capability-and/

7. Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications. PMC. 链接：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589728/

8. 华师大施国跃、张闽等:模块化智能微针平台开启机器学习驱动的个性化健康监测新时代. Nano-Micro Letters. 链接：https://doi.org/10.1007/s40820-026-02095-x

9. A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications. PMC. 链接：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400269/

10. Zhang, Y. et al. (2025). pH-Responsive MOF-Based Microneedles for Targeted Drug Delivery in Tumor Therapy. Journal of Nanobiotechnology. 链接：https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-025-01892-x

11. Li, J. et al. (2024). Peptide-Modified Hydrogel Microneedles for Tissue Regeneration. Biomaterials Science. 链接：https://pubs.rsc.org/en/content/articlelanding/2024/bm/d3bm01876a

第五部分：西安齐岳生物微针定制具体产品列表